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221 Main - Restaurant & Cocktail House

Our Story

Welcome to 221 Main - Restaurant & Cocktail House, an award-winning steakhouse located in the heart of St. Joseph, Michigan. Since 2012, we have been dedicated to providing an unforgettable dining experience with a menu that celebrates exceptional flavor and quality. We pride ourselves on offering a diverse range of dishes, all crafted from the finest ingredients.

At 221 Main, we specialize in steaks. Our offerings include classic cuts like ribeye and filet mignon, available daily to ensure every visit feels like a special occasion. For those seeking something unique, our signature Surf-n-Turf and BC Ribeye, seasoned to perfection, are standout dishes that elevate your dining experience. Each bite reflects our commitment to quality and flavor, making our steaks a memorable part of your visit.

Seafood enthusiasts will appreciate our fresh Atlantic Salmon and Perch, which capture the essence of coastal cuisine. Other popular dishes include Chicken Marsala, creamy Mac & Cheese, and our flavorful Seafood Pasta—each one crafted with care to satisfy every palate. Whether it’s a casual dinner or a special celebration, 221 Main offers a menu sure to delight.

Our vibrant bar scene is the perfect complement to our food. Enjoy hand-crafted cocktails expertly mixed to enhance your meal, or choose from a selection of local craft beers and global wines. With something for every taste, we ensure that your drink experience is as enjoyable as your meal.

221 Main is also an ideal venue for private events, offering event space rentals for gatherings of all sizes. Our private dining options offer a personalized touch for your special occasions. We also offer convenient takeout services, so you can enjoy our cuisine wherever you are.

What truly sets 221 Main apart is our commitment to hospitality. From the moment you walk in, our attentive staff ensures that your dining experience exceeds expectations. Join us at 221 Main - Restaurant & Cocktail House and discover why we’ve become a beloved dining destination in St. Joseph!

What We Offer

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Testimonials

On 4/28/2025 Jevy C had this to say:
Came here on 04/18/2025, but haven’t had a chance to review it until now. Absolutely amazing dining experience—-from the food, to the service, to the atmosphere! Right off the bat, the host was very welcoming and friendly! Our wait staff was Megan J, and she too, was very friendly, with warm smile and was attentive. To start, we had the Seared Ahi Tuna. Taste and presentation was spectacular! In fact, everything was! For drinks, my husband ordered the Smoked Pecan Old Fashioned, and mine was the Spanish Coffee. Both were awesome! In fact, my husband ordered another glass! My little girl got herself a pineapple juice. For the entree, I had the One Lobster Dinner. Right away after tasting it, I wished I ordered 2 because it was perfection! It was perfectly cooked, where it was sweet, tender, bouncy, and juicy! The clarified butter came in its own stand with a tea light candle right below it to keep it nice and warm! My husband ordered the Seafood Pasta and he, too, loved it! My daughter wanted the sirloin from the kid’s menu, so we ordered it medium. It indeed came out perfectly medium and ir was already sliced for her. For dessert, I ordered the crème brûlée. It was a huge portion meant for sharing, except that my husband was too full to share. My daughter being too picky didn’t even touch it, so I couldn’t finish it myself. I wish the caramelized sugar was just a tad thicker because that’s my favorite part! Overall, I can’t wait to be back again! Highly recommend!

On 4/28/2025 Jevy C had this to say:
Came her on 04/18/2025, but haven’t had a chance to review it until now. Absolutely amazing dining experience—-from the food, to the service, to the atmosphere! Right off the bat, the host was very welcoming and friendly! Our wait staff was Megan J, and she too, was very friendly, with warm smile, and attentive. To start, we had the Seared Ahi Tuna. Taste and presentation was spectacular! In fact, everything was! For drinks, my husband ordered the Smoked Pecan Old Fashioned, and mine was the Spanish Coffee. Both were awesome! In fact, my husband ordered another glass! My little girl got herself a pineapple juice. For the entree, I had the One Lobster Dinner. Right away after tasting it, I wished I ordered 2 because it was perfection! It was perfectly cooked, where it was sweet, tender, and juicy! The clarified butter came in its own stand with a tea light candle right below it to keep it nice and warm! My husband ordered the Seafood Pasta and he, too, loved it! My daughter wanted the sirloin from the kid’s menu, so we ordered it medium. It indeed came out perfectly medium and ir was already sliced for her. For dessert, I ordered the crème brûlée. It was a huge portion meant for sharing, except that my husband was too full to share. My daughter being too picky didn’t even touch it, so I couldn’t finish it myself. I wish the caramelized sugar was just a tad thicker because that’s my favorite part! Overall, I can’t wait to be back again! Highly recommend!

On 4/26/2025 Nick Stephens had this to say:
Came in last night and the food was delicious, out server ayana was amazing and did a perfect job with our larger party size. Between the food quality and the customer service I will be back!

On 4/13/2025 Keralyn Totten had this to say:
Went here to celebrate my father’s retirement. The manager was fantastic to work with to make a large party reservation and try to make the night special for my father. The nightly special was prime rib. About half of our part ordered it and it was fabulous! The filet and shrimp was also yummy. Best part was ended the meal with the caramel White Russian. Thank you 221 Main!

On 4/12/2025 Rachael Gardner had this to say:
My husband and I recently attended the ‘whiskey pairing’ dinner at 221 Main, and it was absolutely amazing! Each cocktail was crafted to perfection, and the whiskey selections paired beautifully with all five courses. The atmosphere was intimate and fun, making it a memorable experience. We had a great time with a wonderful group of people and can’t wait to return for more!

Contact Us

221 Main - Restaurant & Cocktail House
221 Main St St joseph, MI 49085
Phone: (269) 982-4000
Email: 221reservations@gmail.com

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Payment Types Accepted

American Express, Android Pay, Apple Pay, Cash, Debit Cards, Discover, MasterCard, Visa

Our Hours

Holiday Hours May Vary. Please Call For Details.

Thursday: 5:00 PM - 9:00 PM
Friday: 5:00 PM - 9:00 PM
Saturday: 5:00 PM - 9:00 PM
Sunday: 5:00 PM - 9:00 PM

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Dinner
Gluten-Free
Dessert
Wine
Whiskey
Cocktail
BARtini
5-Course Whiskey Dinner

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