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221 Main - Restaurant & Cocktail House

Our Story

Welcome to 221 Main - Restaurant & Cocktail House, an award-winning steakhouse located in the heart of St. Joseph, Michigan. Since 2012, we have been dedicated to providing an unforgettable dining experience with a menu that celebrates exceptional flavor and quality. We pride ourselves on offering a diverse range of dishes, all crafted from the finest ingredients.

At 221 Main, we specialize in steaks. Our offerings include classic cuts like ribeye and filet mignon, available daily to ensure every visit feels like a special occasion. For those seeking something unique, our signature Surf-n-Turf and BC Ribeye, seasoned to perfection, are standout dishes that elevate your dining experience. Each bite reflects our commitment to quality and flavor, making our steaks a memorable part of your visit.

Seafood enthusiasts will appreciate our fresh Atlantic Salmon and Perch, which capture the essence of coastal cuisine. Other popular dishes include Chicken Marsala, creamy Mac & Cheese, and our flavorful Seafood Pasta—each one crafted with care to satisfy every palate. Whether it’s a casual dinner or a special celebration, 221 Main offers a menu sure to delight.

Our vibrant bar scene is the perfect complement to our food. Enjoy hand-crafted cocktails expertly mixed to enhance your meal, or choose from a selection of local craft beers and global wines. With something for every taste, we ensure that your drink experience is as enjoyable as your meal.

221 Main is also an ideal venue for private events, offering event space rentals for gatherings of all sizes. Our private dining options offer a personalized touch for your special occasions. We also offer convenient takeout services, so you can enjoy our cuisine wherever you are.

What truly sets 221 Main apart is our commitment to hospitality. From the moment you walk in, our attentive staff ensures that your dining experience exceeds expectations. Join us at 221 Main - Restaurant & Cocktail House and discover why we’ve become a beloved dining destination in St. Joseph!

What We Offer

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Testimonials

On 7/26/2025 Pete Zenisek had this to say:
Always a wonderful experience here. I highly recommend the Lake Perch dinner, it's my go to at this place. The Caesar salad is the best that I've ever had anywhere. Can't leave without the New York cheesecake with tart cherry topping. It's our favorite place for an great meal in the St.Joe area.

On 7/20/2025 david thorn had this to say:
Really good filet. Salad, veggies, & a creme brule.

On 7/10/2025 RoadDog Bermudez had this to say:
Great steaks. ❤️😊🙏🏼

On 6/29/2025 Gustavo Preciado had this to say:
Excellent food, friendly service, and a great atmosphere. Everything was fresh and flavorful—definitely coming back

On 6/9/2025 Mike York had this to say:
We were staying in the area for our 10 year wedding anniversary. We heard great things about this spot and knew we had to check it out. My wife and I enjoyed every bite of our meal and our server was amazing. We felt welcomed and she took time with us on the menu and different options they have. We will definitely tell everyone about our great experience and hope to be back soon! *Edit - my wife and I also come from the food and beverage industry in Vegas. This location is spot on with literally everything. The cuisine, the atmosphere, the service. All extremely well done.

Contact Us

221 Main - Restaurant & Cocktail House
221 Main St St joseph, MI 49085
Phone: (269) 982-4000
Email: 221reservations@gmail.com

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Payment Types Accepted

American Express, Android Pay, Apple Pay, Cash, Debit Cards, Discover, MasterCard, Visa

Our Hours

Holiday Hours May Vary. Please Call For Details.

Wednesday: 4:30 PM - 8:30 PM
Thursday: 4:30 PM - 8:30 PM
Friday: 4:30 PM - 9:00 PM
Saturday: 4:30 PM - 9:00 PM
Sunday: 4:30 PM - 8:30 PM

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