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Name: 221 Main - Restaurant & Cocktail House
Telephone: (269) 982-4000

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221 Main - Restaurant & Cocktail House

Our Story

Welcome to 221 Main - Restaurant & Cocktail House, an award-winning steakhouse located in the heart of St. Joseph, Michigan. Since 2012, we have been dedicated to providing an unforgettable dining experience with a menu that celebrates exceptional flavor and quality. We pride ourselves on offering a diverse range of dishes, all crafted from the finest ingredients.

At 221 Main, we specialize in steaks. Our offerings include classic cuts like ribeye and filet mignon, available daily to ensure every visit feels like a special occasion. For those seeking something unique, our signature Surf-n-Turf and BC Ribeye, seasoned to perfection, are standout dishes that elevate your dining experience. Each bite reflects our commitment to quality and flavor, making our steaks a memorable part of your visit.

Seafood enthusiasts will appreciate our fresh Atlantic Salmon and Perch, which capture the essence of coastal cuisine. Other popular dishes include Chicken Marsala, creamy Mac & Cheese, and our flavorful Seafood Pasta—each one crafted with care to satisfy every palate. Whether it’s a casual dinner or a special celebration, 221 Main offers a menu sure to delight.

Our vibrant bar scene is the perfect complement to our food. Enjoy hand-crafted cocktails expertly mixed to enhance your meal, or choose from a selection of local craft beers and global wines. With something for every taste, we ensure that your drink experience is as enjoyable as your meal.

221 Main is also an ideal venue for private events, offering event space rentals for gatherings of all sizes. Our private dining options offer a personalized touch for your special occasions. We also offer convenient takeout services, so you can enjoy our cuisine wherever you are.

What truly sets 221 Main apart is our commitment to hospitality. From the moment you walk in, our attentive staff ensures that your dining experience exceeds expectations. Join us at 221 Main - Restaurant & Cocktail House and discover why we’ve become a beloved dining destination in St. Joseph!

What We Offer

Our Specialties include:

Award Winning Steakhouse and Cocktail Lounge
The Terrace
Copper Pot Breakfast Cafe
The Largest Whiskey In The State
335 Whiskeys From Around The World
Delicious Seafood
Parmesan Encrusted Whitefish
Child-Friendly
Gluten-Free Options

Our Services include:

Weddings
Rehearsal Dinners
Private Dining
Event Catering
Takeout
Customizable Event Menus
Bar Service
Event Space Rental
Outdoor Seating
Waitlist Management
Catering
Seasonal Menus
Event Hosting
Corporate Catering
Coffee Bar
Sustainable Packages
Online Reservations
Brunch
Breakfast

Our Products include:

Surf and Turf
Filet Mignon
Shrimp
Garlic Ribeye
Steak Fries
Roasted Whitefish
Blackened Salmon
Lake Perch
Seafood Pasta
Short Ribs
Sirloin
Steakhouse Burgers
Chicken Marsala
Eggs Benedict
Bloody Marys
Wines
Draft Beers
Craft Cocktails
Champagne
Prosecco

Testimonials

On 9/7/2025 Nick B had this to say:
Good value, good food, and excellent pecan old fashioned.

On 9/2/2025 Brett Edwards had this to say:
Amazing spot for dinner and cocktails! From the atmosphere to the food & drinks to the service, 221 Main is top notch and I'd recommend it as a place to eat if you're ever in the area. Will definitely be returning!

On 9/1/2025 Tina Schuler had this to say:
Absolutely loved the atmosphere and the chicken marsala was delicious! We sat on the upstairs floor, which was indoor/outdoor with a terrace. Would definitely come back!

On 8/28/2025 Aline Ferreira had this to say:
I celebrated my birthday today with friends at 221’s rooftop. Not only do they have the best steaks in town, but also the friendliest team who did everything possible to accommodate our requests and make sure we had a memorable dinner. I am beyond happy with my experience!

On 8/26/2025 Sheetal Gowda had this to say:
we had dinner at the rooftop and it was a beautiful place! the cocktails were delicious and we also loved the bread rolls. I got the spring risotto with blackened chicken and my friend got a steak, both were amazing and the mashed potatoes were some of the best ever! pro tip: since the St. Joseph Downtown District allows you to drink on the streets, you can take your drinks to go if you don't finish and want to walk around a bit with them.

Contact Us

221 Main - Restaurant & Cocktail House
221 Main St St joseph, MI 49085
Phone: (269) 982-4000
Email: 221reservations@gmail.com

Where To Find Us

Payment Types Accepted

American Express, Android Pay, Apple Pay, Cash, Debit Cards, Discover, MasterCard, Visa

Our Hours

Holiday Hours May Vary. Please Call For Details.

Wednesday: 4:30 PM - 8:30 PM
Thursday: 4:30 PM - 8:30 PM
Friday: 4:30 PM - 9:00 PM
Saturday: 4:30 PM - 9:00 PM
Sunday: 4:30 PM - 8:30 PM

Info

Dinner
Gluten-Free
Dessert
Wine
Whiskey
Cocktail
BARtini